Monson shares the stories of twelve women who heard the call to settle the west and came from all points of the globe to begin their journey. As a slave, Clara watched helpless as her husband and children were sold, only to be reunited with her youngest daughter six decades later. Charlotte hid her gender to escape a life of poverty and became the greatest stagecoach driver that ever lived. A Native American, Gertrude fought to give her people a voice and to educate leaders about the ways and importance of America's native people. All endured hardships, overcame obstacles, and changed the world.